The topic acrokeratosis verruciformis you are seeking is a synonym, or alternative name, or is closely related to the medical condition acrokeratosis verruciformis of hopf. In a recent study of a wartlike eruption of the hands and feet in a boy of 17 years, investigation revealed a familial incidence of the disease involving no less than 14 members of the family in four generations. Acrokeratosis verruciformis medigoo health medical. It has been theorized that the mutation in atp2a2 causes. Note that this may not provide an exact translation in all languages. Acrokeratosis verruciformis of hopf avh is a rare, benign skin condition, characterised by wartlike papules on the hands and feet. Acrokeratosis verruciformis is a rare autosomal dominant disorder appearing at birth or in early childhood, characterized by skin lesions that are small, verrucous, flat papules resembling warts along with palmoplantar punctate keratoses and pits. Acrokeratosis verruciformis of hopf avh is a rare, autosomal dominant genodermatosis that was first described by hopf in 1931. Nilofar g diwan, nidhi b jivani, pragya ashok nair department of dermatology and venereology, pramukhswami medical college, karamsad, gujarat, india. Acrokeratosis verruciformis of hopfomicsgroupjournal of.
It may be caused by genetics, uv rays or immunosuppression. Some lesions can develop into malignant carcinomas. Answers from doctors on treatments for parakeratosis. Acrokeratosis verruciformis of hopf clinically mimicking. It is characterized by multiple, localized, symmetrical, flat, skincolored, wartlike lesions, typically. Porokeratosis is a medical condition in which the process of keratinization is affected and disrupted. Acrokeratosis verruciformis is a rare genodermatosis with an autosomal dominant mode of inheritance. Not only is the terminology confusing, but some normal oral mucosal structures, inflammatory polyps and viral papillomas as well as dysplastic and malignant lesions may share microscopic appearances. Parakeratosis medical definition merriamwebster medical. However sporadic forms, whose less than 10 cases have been reported, presents at a later age, usually after the first decade and generally lack. Porokeratosis is a skin condition involving lesions with thin center surrounded by raised ridges. Skin inflammatory nontumor epidermodysplasia verruciformis.
Journal of infectious diseases and salman and osman nfect. It is a useful feature for classifying certain types of dermatitis. Porokeratosis treatment, pictures, symptoms and causes. Serarslan g, balci dd, homan s 2007 acitretin treatment in acrokeratosis verruciformis of hopf. Parakeratosis pustulosa is a condition exclusively seen in children aged from 5 to 7 years and usually involves a single digit of the hand, often the thumb or index finger. Mar 25, 2018 acrokeratosis verruciformis of hopf avh is a rare, benign skin condition, characterised by wartlike papules on the hands and feet. Keratosis pilaris is often treated with topical exfoliants, topical retinoids or laser therapy. Acrokeratosis verruciformis of hopf is an autosomal dominant genodermatosis usually presenting with multiple planar wartlike lesions, typically observed on the dorsum of the hands and feet. May 11, 2018 acrokeratosis verruciformis is a rare genodermatosis with an autosomal dominant mode of inheritance. Acrokeratosis verruciformis of hopf is an autosomal dominant genodermatosis of unknown etiology, with no sexual predilection. It has autosomal dominant inheritance, meaning that only one copy of the affected gene needs to be inherited to develop the disease. Papillary and verrucous lesions of the oral mucosa. If one parent is affected, the chance of a child developing acrokeratosis verruciformis of hopf is 1 in 2 50%.
Acrokeratosis verruciformis of hopf rege v l, hede r v. A distinct darier phenotype presenting with confettilike hypopigmented macules was first described in 1965. Acrokeratosis verruciformis of hopf akv is a rare autosomal dominant cutaneous disorder first described by hopf in 1931. Acrokeratosis verruciformis of hopf is a rare heritable autosomal dominant genodermatosis and keratinization disorder, first described in 1931 by. Designated as guttate leukoderma, this skin finding is a rarelyreported presentation of darier disease. These are usually present from birth or early childhood but occasionally arise in adult life. Guttate leukoderma and acrokeratosis verruciformis of hopf. Download fulltext pdf verrucous porokeratosis porokeratosis ptychotropica with dermal amyloid deposits article pdf available in dermatologica sinica 3. Characteristic findings on physical examination findings include multiple flattopped skincolored keratotic papules akin to verruca planae flat warts. Acrokeratosis definition of acrokeratosis by medical dictionary.
In the first stage, the affected digit presents an eczema with erythema, scaling, and vesicles and then, as it advances, shows psoriasiform signs with subungual. If one parent is affected, the chance of a child developing acrokeratosis verruciformis of hopf is. Porokeratosis has been associated with names like seborrheic verruca, senile warts, and barnacles to mention just but a few. It is characterized by multiple, localized, symmetrical, flat. Pdf verrucous porokeratosis porokeratosis ptychotropica. It typically presents as multiple, small, flat, wartlike papules on the dorsum of the hands and feet and arises in early life, often at birth or infancy, with no sexual predilection 2, 3. The disease is very rare and the pathogenesis remains unknown. Files are available under licenses specified on their description page. Parakeratosis is relatively common in both benign and malignant skin diseases. It is a genetic disorder that is usually manifested at or following the birth of the child. Acrokeratosis verruciformis of hopf is an autosomal dominant genodermatosis usually presenting with multiple planar wartlike lesions, typically observed on the dorsum of the hands, feet, elbows, and knees.
Epidermodysplasia verruciformis accessed 29 august 2018. There are few more diagnostically challenging areas of oral pathology than papillary and verrucous lesions. However, according to some authors, large numbers of neutrophils in parakeratosis in the viable epidermis or neutrophils forming intraepidermal collections, as well as more numerous extravasated erythrocytes in the epidermis and necrosis more emphasized in the upper part of the epidermis, are features more common in hfmd 24, which was also present in our case to some extent. It is characterized by multiple, skincolored, flattopped, hyperkeratotic papules on the dorsal aspects of the hands and feet, which occasionally extend to the forearms and lower legs. The most distinctive feature is the border surrounding the patch, this being obviously hyperkeratotic. Acrokeratosis verruciformis is a disorder of keratinization characterized by multiple flattopped, skincolored keratotic lesions resembling plane warts typically observed on the dorsum of the hands and feet. Parakeratosis article about parakeratosis by the free. Acrokeratosis verruciformis akv is a rare hyperkeratotic genodermatosis, which was first described by hopf in 1931 1. Acrokeratosis verruciformis of hopf differential diagnoses. Sep 12, 2017 porokeratosis is a rare skin disorder affecting fewer than 200,000 americans. Acrokeratosis verruciformis of hopf is a rare disorder and characterized by fleshcoloured, wartlike, flat papules on the dorsum of the hands and feet. The leading primary care society for dermatology and skin surgery.
Pathology outlines epidermodysplasia verruciformis. Acrokeratosis definition of acrokeratosis by medical. Acrokeratosis verruciformis of hopf avh is a rare genodermatosis characterized by keratotic lesions on the dorsum of the hands and feet. The patient presents patches of atrophy on the skin, these having distinctive clinical and histopathological features. It typically presents as small, round patches on your skin that have a thin, raised border. This is because the condition is caused by excessive exposure of the skin to the suns ultraviolet radiation. Acrokeratosis verruciformis of hopf clinically mimicking epidermodysplasia verruciformis. Acrokeratosis verruciformis medigoo health medical tests. Acrokeratosis verruciformis of hopf is due to an abnormal atp2a2 gene. Pdf nonfamilial acrokeratosis verruciformis of hopf. Apart from the typical skincolored, flat, warty papules on the dorsum of the hands and feet, examination may reveal thickening of palmar skin and punctate keratoses on the palms and the soles 2. Acrokeratosis verruciformis is a very rare, heritable hyperkeratotic dermatosis that was originally described by hopf in 1931.
Here are links to possibly useful sources of information about acrokeratosis verruciformis. Acrokeratosis verruciformis of hopf is a rare genodermatosis best characterized within the disorders of keratinization. Acrokeratosis verruciformis of hopf is characterised by multiple, flattopped, symmetrical, skin coloured keratotic lesions on the dorsum of the hands and feet. Disseminated superficial actinic porokeratosis dsap this is the most common variety and arises in middleaged individuals. Porokeratosis is a skin condition that is very prevalent in adults, especially women. All structured data from the file and property namespaces is available under the creative commons cc0 license. Different types include porokeratosis of mibelli, linear porokeratosis and disseminated superficial actinic porokeratosis dsap. Tell a friend about us, add a link to this page, or visit the webmasters page for free fun. Congenital or posttransplant abnormal susceptibility to clinical hpv infection, which causes only asymptomatic infections in 80% of normal population wikipedia. It occurs as a result of quick growth of some parts of skin resulting to thickening of the skin area. A congenital disorder characterized by warty papules of the hands, feet, knees, and elbows. It is an autosomal dominant condition, but a history of chronic uv exposure also appears to be needed. Lesions are predominantly found on sunexposed areas of the legs, and less so the arms.
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